B inflammatory pathway by inhibiting AKR1B1, resulting in reduced inflammatory cytokine levels in renal tissues and blood. This mitigated renal tissue injuries and improved the systemic inflammatory response in the severe sepsis rat model. Consequently, AKR1B1 holds promise as a target for treating sepsis-associated acute kidney injuries.
Keyphrases
- acute kidney injury
- inflammatory response
- cardiac surgery
- septic shock
- intensive care unit
- oxidative stress
- drug induced
- liver failure
- mass spectrometry
- gene expression
- signaling pathway
- early onset
- lipopolysaccharide induced
- hepatitis b virus
- immune response
- lps induced
- big data
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- machine learning