Bystander effects induced by electron beam-irradiated MCF-7 cells: a potential mechanism of therapy resistance.

Maryam FeghhiJafar RezaieKamal MostafanezhadNasrollah Jabbari

Published in: Breast cancer research and treatment (2021)

MCF-7 cells treated with an electron beam and CMs from irradiated MCF-7 cells exhibit an up-regulation in both genes involved in the apoptosis pathway and stemness. As a result, EBI can affect apoptosis and stemness in MCF-7 cells in direct and bystander manners. However, specific signaling pathways require careful evaluation to provide an understanding of the mechanisms involved in the EBI-induced alternation in tumor cell dynamics.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
oxidative stress
pi k akt
signaling pathway
breast cancer cells
epithelial mesenchymal transition
mesenchymal stem cells
risk assessment
bone marrow
drug induced
newly diagnosed
human health
stress induced