A hitherto unknown stability of DNA basepairs.

Published in: Chemical communications (Cambridge, England) (2021)

The resonance capture of ubiquitous very low energy electrons (vLEEs) into the π* orbitals of nucleobases is a potential doorway to DNA damage. Our ab initio quantum chemical calculations reveal a possible protection function, which is specific to the complementary basepairing, against such vLEE induced DNA damage.

Keyphrases

dna damage
density functional theory
molecular dynamics
oxidative stress
energy transfer
dna repair
diabetic rats
high glucose
circulating tumor
monte carlo
genome wide
single molecule
molecular dynamics simulations
single cell
drug induced
human health
gene expression
climate change