Boesenmaxane Diterpenoids from Boesenbergia maxwellii.
The Su MoeSuppisak ChaturonrutsameeSamreang BunteangChutima KuhakarnSamran PrabpaiPanida SurawatanawongArthit ChairoungduaKanoknetr SuksenRadeekorn AkkarawongsapatJitra LimthongkulChanita NapaswadNarong NuntasaenVichai ReutrakulPublished in: Journal of natural products (2020)
Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.
Keyphrases
- high resolution
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hiv testing
- hepatitis c virus
- molecular docking
- electronic health record
- hiv aids
- high throughput
- electron microscopy
- men who have sex with men
- density functional theory
- dual energy
- south africa
- computed tomography
- genetic diversity
- magnetic resonance