Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study.
Xin WangGeertje W DalmeijerHester M den RuijterTodd J AndersonAnnie R BrittonJacqueline DekkerGunnar EngströmGreg W EvansJacqueline de GraafDiederick E GrobbeeBo HedbladSuzanne HolewijnAi IkedaJussi KauhanenKazuo KitagawaAkihiko KitamuraSudhir KurlEva M LonnMatthias W LorenzEllisiv B MathiesenGiel NijpelsShuhei OkazakiJoseph F PolakJacqueline F PriceChristopher M RemboldMaria RosvallTatjana RundekJukka T SalonenMatthias SitzerCoen D A StehouwerTomi-Pekka TuomainenSanne A E PetersMichiel L BotsPublished in: PloS one (2017)
Clusters of risk factors relate to increased common CIMT in a graded manner, similar in men, women and across race-ethnic groups. Some clusters seemed more atherogenic than others. Our findings support the notion that cardiovascular prevention should focus on sets of risk factors rather than individual levels alone, but may prioritize within clusters.