Methylation of SERPINA1 gene promoter may predict chronic obstructive pulmonary disease in patients affected by acute coronary syndrome.

John Charles RotondoGiorgio AquilaLucia Oton-GonzalezRita SelvaticiPaola RizzoMonica De MatteiRita PavasiniMauro TognonGianluca Calogero CampoFernanda Martini

Published in: Clinical epigenetics (2021)

SERPINA1 is hypermethylated in blood cells from COPD+ patients. COPD- carrying SERPINA1 hypermethylated and high lymphocytes count may be at risk of COPD development. Therefore, SERPINA1 hypermethylation may represent a potential biomarker for predicting COPD development in ACS patients.

Keyphrases

chronic obstructive pulmonary disease
end stage renal disease
acute coronary syndrome
ejection fraction
newly diagnosed
chronic kidney disease
lung function
peritoneal dialysis
prognostic factors
gene expression
patient reported outcomes
cystic fibrosis
air pollution
antiplatelet therapy