Discovery of high-expressing lncRNA-derived sORFs as potential tumor-associated antigens in hepatocellular carcinoma.

Published in: Genes & genomics (2024)

This study uncovers the as-yet-unknown potential of lncRNA-derived sORFs as sources of tumor antigens, shifting the research focus from protein-coding genes to non-coding RNAs also in the HCC context. Moreover, this study highlights the contribution of a subset of lncRNAs, especially LINC00152, to the development of tumors and modulation of the immune response by its sORFs.

Keyphrases

immune response
long non coding rna
dendritic cells
long noncoding rna
small molecule
gene expression
risk assessment
toll like receptor
network analysis
bioinformatics analysis