Plasticity within Aldehyde Dehydrogenase-Positive Cells Determines Prostate Cancer Radiosensitivity.

Franziska M SchwarzIñaki Schniewind Maria J Besso Steffen Lange Annett LingeShivaprasad G PatilSteffen LoeckDaria KlusaAntje Dietrich Anja Voß-BöhmeAli NowrouziMechthild KrauseAnna DubrovskaIna KurthClaudia Peitzsch

Published in: Molecular cancer research : MCR (2022)

The increase of ALDH+ cells with stem-like features in prostate xenograft tumors after local irradiation represents a putative cellular escape mechanism inducing tumor radioresistance.

Keyphrases

prostate cancer
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
radiation therapy
dna damage
radiation induced
benign prostatic hyperplasia
dna repair