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Visualising the membrane viscosity of porcine eye lens cells using molecular rotors.

Peter S SherinIsmael López-DuarteMichael R DentMarkéta KubánkováAurimas VyšniauskasJames A BullEvdokiya S ReshetnikovaAndrey S KlymchenkoYuri P TsentalovichMarina K Kuimova
Published in: Chemical science (2017)
The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive 'molecular rotors' to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • stem cells
  • oxidative stress
  • mesenchymal stem cells
  • cell therapy
  • bone marrow
  • cell proliferation
  • single molecule