Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury.

Bahjat Al-AniNorah M AlzamilPeter W HewettFahaid Al-HashemIsmaeel Bin-JaliahAbdullah S ShatoorAbeer Ibraheem OmarNoha S Abdel LatifMohamed A HaidaraAmal F Dawood

Published in: Archives of physiology and biochemistry (2021)

These findings show that metformin provides substantial protection against diabetic cardiomyopathy-induced ROS-p53 mediated fibrosis and dyslipidemia.

Keyphrases

left ventricular
high glucose
diabetic rats
heart failure
dna damage
cell death
type diabetes
reactive oxygen species
drug induced
endothelial cells
coronary artery disease
stress induced