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Global and local ancestry estimation in a captive baboon colony.

Christopher KendallJacqueline RobinsonGuilherme DebortoliAmin NooranikhojastehDebbie ChristianDeborah E NewmanKenneth SayersShelley ColeEsteban ParraMichael SchillaciBence Viola
Published in: PloS one (2024)
The last couple of decades have highlighted the importance of studying hybridization, particularly among primate species, as it allows us to better understand our own evolutionary trajectory. Here, we report on genetic ancestry estimates using dense, full genome data from 881 olive (Papio anubus), yellow (Papio cynocephalus), or olive-yellow crossed captive baboons from the Southwest National Primate Research Center. We calculated global and local ancestry information, imputed low coverage genomes (n = 830) to improve marker quality, and updated the genetic resources of baboons available to assist future studies. We found evidence of historical admixture in some putatively purebred animals and identified errors within the Southwest National Primate Research Center pedigree. We also compared the outputs between two different phasing and imputation pipelines along with two different global ancestry estimation software. There was good agreement between the global ancestry estimation software, with R2 > 0.88, while evidence of phase switch errors increased depending on what phasing and imputation pipeline was used. We also generated updated genetic maps and created a concise set of ancestry informative markers (n = 1,747) to accurately obtain global ancestry estimates.
Keyphrases
  • genome wide association study
  • genome wide
  • quality improvement
  • patient safety
  • copy number
  • electronic health record
  • current status
  • big data
  • social media
  • artificial intelligence