Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in DLBCL.
Zijun Y Xu-MonetteYong LiThomas SnyderTiantian YuTingxun LuAlexandar TzankovChiara RusconiGovind BhagatWeidong HanKaren DybkærApril ChiuWayne TamYouli ZuEric D HsiFredrick B HagemeisterYingjun WangHeounjeong GoMaurilio PonzoniAndrés José Maria FerreriMichael Boe MøllerBenjamin M ParsonsXiangshan FanJ Henricus van KriekenMiguel Angel PirisJane N WinterQingyan AuIlan R KirschMing-Zhi ZhangJohn ShaughnessyBing XuKen H H YoungPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
TIL-B frequency is a significant prognostic factor in DLBCL and plays a crucial role in antitumor immune responses. This study provides novel insights into the prognostic determinants in DLBCL and TIL-B functions with important therapeutic implications.