Common founder BRCA2 pathogenic variants and breast cancer characteristics in Ethiopian Jews.
Sari LiebermanR Chen-ShtoyermanZ LeviS Shkedi-RafidS ZuckermanR Bernstein-MolhoG Reznick LeviS S ShacharA FlugelmanV LibmanI KedarS Naftaly-NathanI LagovskyT PeretzN KarminskyS CarmiE Levy-LahadY GoldbergPublished in: Breast cancer research and treatment (2022)
EJs harbor 3 recurrent BRCA2 PVs presenting with relatively severe breast cancer morbidity. Combined with the high BRCA2 carrier rate in the EJ population, these findings merit increasing awareness in this community and suggest that a culturally adapted population screening approach may be warranted.