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Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.

Chunlin ZhangZhiping YangPing LuoMengxia YePing GongQuan GongBing Mei
Published in: Biomarkers in medicine (2023)
Aim: Toll-like receptors involved in tumor-associated inflammatory response, this study aimed to investigate the role of TLR4 and TLR9 gene polymorphisms in the risk and progression of HPV-related cervical lesions. Materials & methods: A total of 220 cervical lesion patients and 227 healthy controls were enrolled. Single-nucleotide polymorphisms were genotyped using PCR-restriction fragment length polymorphism. Results: A significantly decreased risk of cervical lesions was observed to be associated with the TLR4 rs10116253 (C), rs1927911 (T) and rs10759931 (G) mutant alleles. rs187084-rs1927911-HPV-16/18 was the best interaction model to affect cervical lesion risk. Conclusion: TLR4 rs10116253, rs1927911 and rs10759931 were potential biomarkers for cervical lesion susceptibility.
Keyphrases
  • inflammatory response
  • toll like receptor
  • immune response
  • lipopolysaccharide induced
  • nuclear factor
  • end stage renal disease
  • lps induced
  • chronic kidney disease
  • newly diagnosed
  • type diabetes
  • breast cancer risk