RET overexpression leads to increased brain metastatic competency in luminal breast cancer.
Petra JagustAoibhin M PowellMihaela OlaLouise WatsonAna de Pablos-AragonesesPedro García-GómezRamón FallonFiona BaneMona HeilandGareth MorrisBrenton CavanaghJason McGrathDaniela OttavianiAisling HegartySinéad CocchigliaKieron J SweeneyStephen MacNallyFrancesca M BrettJane CryanAlan BeausangPatrick MorrisManuel ValienteArnold D K HillDamir VarešlijaLeonie S YoungPublished in: Journal of the National Cancer Institute (2024)
Our results illustrate, for the first time, the role of RET in regulating colonization and outgrowth of breast cancer brain metastasis and provide data to support the use of RET inhibitors in the management strategy for patients with breast cancer brain metastases.