White Matter Hyperintensities and Hippocampal Atrophy in Relation to Cognition: The 90+ Study.

Nienke LegdeurPieter Jelle VisserDavis C WoodworthMajon MullerEvan FletcherPauline MaillardPhilip ScheltensCharles DeCarliClaudia H KawasMaría M Corrada

Published in: Journal of the American Geriatrics Society (2019)

We show that WMH and hippocampal atrophy have an independent, negative effect on cognition that make these biomarkers relevant to evaluate in the diagnostic work-up of the oldest-old individuals with cognitive complaints. However, the predictive value of WMH for cognitive decline seems to be less evident in the oldest-old compared with a younger group of older adults. J Am Geriatr Soc 67:1827-1834, 2019.

Keyphrases

cognitive decline
mild cognitive impairment
white matter
multiple sclerosis
physical activity
cerebral ischemia
brain injury
subarachnoid hemorrhage