Improved contingent screening strategy increased trisomy 21 detection rate in the second trimester.

Wei LuoBin HeDaiwen HanLixing YuanJun TangLing PangKai ZhaoFene ZouTing HuShanling Liu

Published in: Archives of gynecology and obstetrics (2024)

Utilizing threshold values of AFP, free β-hCG, and uE3 to trigger further non-invasive prenatal screening may increase trisomy 21 detection in pregnancies deemed low risk in the second trimester while reducing the overall costs of screening strategies.

Keyphrases

preterm birth
gestational age
pregnancy outcomes
loop mediated isothermal amplification
label free
real time pcr
sensitive detection