Plant-produced chimeric virus-like particles - a new generation vaccine against African horse sickness.

Daria A RutkowskaNobalanda B MokoenaTsepo L TsekoaVusi S DibakwaneMartha M O'Kennedy

Published in: BMC veterinary research (2019)

We have successfully shown assembly of single and double chimeric AHSV-7 VLPs, as well as triple chimeric AHSV-6 VLPs, in Nicotiana benthamiana dXT/FT plants. Plant produced chimeric AHSV-6 VLPs were found to be safe for administration into 6 month old foals as well as capable of eliciting a weak neutralizing humoral immune response in these target animals against homologous AHSV virus.

Keyphrases

cell therapy
immune response
stem cells
mesenchymal stem cells
toll like receptor
inflammatory response