Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability.

Santiago Gerardo Medina-MuñozGopal KushawahLuciana Andrea CastellanoMichay DiezMichelle Lynn DeVoreMaría José Blanco SalazarAriel Alejandro Bazzini

Published in: Genome biology (2021)

By integrating the contributions of different regulatory mechanisms, our work provides a framework for understanding how combinatorial control of mRNA stability shapes the gene expression landscape.

Keyphrases

gene expression
transcription factor
dna methylation
binding protein
single cell