TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis.
Phillip S CoburnFrederick C MillerAustin L LaGrowSalai Madhumathi ParkunanC Blake RandallRachel L StaatsMichelle C CalleganPublished in: BMC ophthalmology (2018)
Our results have identified a cohort of mediators driven by TLR4 that may be important in regulating pro-inflammatory and protective pathways in the retina in response to B. cereus intraocular infection. This supports the prospect that blocking the activation of TLR-based pathways might serve as alternative targets for Gram-positive and Gram-negative endophthalmitis therapies in general.