Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis.

Guendalina OliveroAlice TaddeucciGiulia VallarinoHanna TrebesovaAlessandra RoggeriMaria Cristina GaglianiKatia CorteseMassimo GrilliAnna Pittaluga

Published in: British journal of pharmacology (2024)

Our results unveil a new noncanonical role of complement in the CNS of EAE mice relevant to disease progression and central synaptopathy that suggests new therapeutic targets for the management of MS.

Keyphrases

multiple sclerosis
white matter
mass spectrometry
high fat diet induced
blood brain barrier
ms ms
adipose tissue
prefrontal cortex
type diabetes
metabolic syndrome