Pulmonary artery pressure may be a predictor of closed aortic valve in patients managed by venoarterial extracorporeal membrane oxygenation.
Shogo YamaguchiAkinori SawamuraTakahiro OkumuraHiroo KatoHideo OishiYoshihito AraoTomoaki HagaTasuku KuwayamaTsuyoshi YokoiHiroaki HiraiwaToru KondoRyota MorimotoToyoaki MuroharaPublished in: The International journal of artificial organs (2020)
In the management of venoarterial extracorporeal membrane oxygenation, some patients present persistently closed aortic valve. However, little is known about the variables that contribute to persistently closed aortic valve. We investigated the factors that could predict persistently closed aortic valve at the time of venoarterial extracorporeal membrane oxygenation initiation. We investigated 17 patients who presented closed aortic valve immediately after the introduction of venoarterial extracorporeal membrane oxygenation. Patients who presented closed aortic valve 24 h after introduction of venoarterial extracorporeal membrane oxygenation were defined as the Closed-AV group (n = 8), while those whose aortic valve remained opened after 24 h were defined as the Open-AV group (n = 9). All patients were managed by concomitant use of intra-aortic balloon pumping. At baseline, there were no significant differences between mean arterial blood pressure, central venous pressure, and left ventricular ejection fraction. However, Closed-AV group had significantly lower mean pulmonary artery pressure and pulmonary artery pulse pressure compared to those of Open-AV group (mean pulmonary artery pressure: 15 ± 6 mmHg vs 25 ± 8 mmHg, p = 0.01; pulmonary artery pulse pressure: 3 ± 2 mmHg vs 8 ± 3 mmHg, p < 0.01). Logistic regression analyses revealed that the lower mean pulmonary artery pressure and pulmonary artery pulse pressure had the predictive value of closed aortic valve within 24 h after venoarterial extracorporeal membrane oxygenation initiation (mean pulmonary artery pressure: odds ratio = 0.78, 95% confidence interval = 0.58-0.95, p < 0.01; pulmonary artery pulse pressure: odds ratio = 0.18, 95% confidence interval = 0.01-0.61, p < 0.01). Lower mean pulmonary artery pressure and pulmonary artery pulse pressure values could predict persistent closed aortic valve 24 h after venoarterial extracorporeal membrane oxygenation initiation. Left ventricular preload derived from right heart function may have a major impact on aortic valve status.
Keyphrases
- pulmonary artery
- extracorporeal membrane oxygenation
- aortic valve
- aortic stenosis
- coronary artery
- acute respiratory distress syndrome
- pulmonary hypertension
- transcatheter aortic valve replacement
- pulmonary arterial hypertension
- ejection fraction
- transcatheter aortic valve implantation
- aortic valve replacement
- blood pressure
- respiratory failure
- left ventricular
- newly diagnosed
- heart failure
- mechanical ventilation
- prognostic factors
- skeletal muscle
- intensive care unit
- atrial fibrillation
- heart rate
- high resolution
- minimally invasive
- acute myocardial infarction
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- high speed