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A DNA element that remembers winter.

Chenlong LiYuhai Cui
Published in: Nature genetics (2017)
Polycomb-mediated silencing of the floral repressor gene FLC in response to long-term cold is a central event during vernalization in Arabidopsis thaliana, but how it is initiated is unclear. Two new studies identify a DNA element that mediates FLC silencing by attracting a pair of transcriptional repressors, VAL1 and VAL2, which in turn trigger epigenetic silencing by the Polycomb complex PHD-PRC2.
Keyphrases
  • heat stress
  • arabidopsis thaliana
  • gene expression
  • dna methylation
  • circulating tumor
  • genome wide
  • transcription factor
  • cell free
  • single molecule
  • fluorescent probe
  • sensitive detection
  • nucleic acid