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Juvenile xanthogranuloma: A herald to the diagnosis of Erdheim-Chester disease in an adult with acute leukemia.

Gabriela Sanchez-PetittoTaylor C DukeMichael SwabyGabriel M Aisenberg
Published in: Journal of cutaneous pathology (2018)
A 21-year-old man with B-cell acute lymphoblastic leukemia developed an eruption of multiple flesh-colored nodules and persistent fevers. A lesional biopsy showed diffuse dermal infiltrates of histiocytes, foam cells, and Touton giant cells consistent with juvenile xanthogranulomatosis. Upon further investigation, the patient's constellation of findings fit criteria for Erdheim-Chester disease.
Keyphrases
  • induced apoptosis
  • acute lymphoblastic leukemia
  • cell cycle arrest
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • cell death
  • cell proliferation
  • pi k akt
  • ultrasound guided