14-3-3 proteins regulate cullin 7-mediated Eag1 degradation.

Chang-Heng HsiehChia-Cheng ChouYa-Ching FangPo-Hao HsuYi-Hung ChiuChi-Sheng YangGuey-Mei JowChih-Yung TangChung-Jiuan Jeng

Published in: Cell & bioscience (2023)

Overall these results highlight a chaperone-like role of endogenous 14-3-3 proteins in regulating Eag1 protein homeostasis, as well as a therapeutic potential of 14-3-3 modulators in correcting defective protein expression of disease-causing Eag1 mutants.

Keyphrases

small molecule
protein protein
heat shock protein
amino acid
binding protein