Effects of ethanol on mechanical allodynia and dynamic weight bearing in male and female mice with spared nerve injury.
Mitchell A NothemJason R WickmanLaura L GiacomettiJacqueline M BarkerPublished in: Alcoholism, clinical and experimental research (2022)
These data indicate that while ethanol has antiallodynic and antinociceptive effects in males and female mice, the doses and time course of these effects are distinct. Studies investigating the relationship between pain and ethanol in mice should consider sex as a key variable. These data further inform reported sex differences in rodent models of chronic pain and in chronic pain patients.
Keyphrases
- chronic pain
- high fat diet induced
- pain management
- neuropathic pain
- end stage renal disease
- ejection fraction
- electronic health record
- chronic kidney disease
- peritoneal dialysis
- physical activity
- body mass index
- big data
- prognostic factors
- type diabetes
- weight loss
- spinal cord injury
- insulin resistance
- wild type
- adipose tissue
- skeletal muscle
- case control
- deep learning