In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion.
Stella F S XuDaniel B AndersenJose M G IzarzugazaRune Ehrenreich KuhreJens Juul HolstPublished in: Acta physiologica (Oxford, England) (2020)
Somatostatin is a powerful and tonic inhibitor of glucagon secretion from the rat pancreas and is required for glucose to inhibit glucagon secretion.