Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort.
Kyle Gregory MitchellLixia DiaoTatiana KarpinetsMarcelo V NegraoHai T TranEdwin R ParraErin M CorsiniAlexandre ReubenLorenzo FedericoChantale BernatchezHitoshi DejimaAlejandro Francisco-CruzJing WangMara B AntonoffAra A VaporciyanStephen G SwisherTina CasconeIgnacio I WistubaJohn V HeymachDon L GibbonsJianjun ZhangCara L HaymakerBoris SepesiPublished in: Journal for immunotherapy of cancer (2021)
Our findings demonstrate that neutrophil expansion reflects protumorigenic and immunosuppressive processes that manifest as worse OS in patients undergoing NSCLC resection. These results justify further investigation of therapeutic strategies targeting neutrophil-associated immune evasion.