CARD8 makes coxsackievirus more "heartbreaking".

Published in: The Journal of experimental medicine (2022)

In this issue of JEM, Nadkarni et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212117) identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.

Keyphrases

endothelial cells
left ventricular
immune response
oxidative stress
aortic valve
sars cov
heart failure
nlrp inflammasome
high glucose
pulmonary artery
atrial fibrillation
aortic dissection