One of the features that differentiate cancer cells is their increased proliferation rate, which creates an opportunity for general anti-tumor therapy directed against the elevated activity of replicative apparatus in tumor cells. Besides DNA synthesis, successful genome replication requires the reparation of the newly synthesized DNA. Malfunctions in reparation can cause fatal injuries in the genome and cell death. Recently we have found that the ultra-short single-stranded deoxyribose polynucleotides of random sequence (ssDNA) effectively inhibit the catalytic activity of DNA polymerase [Formula: see text]. This effect allowed considering these substances as potential anti-tumor drugs, which was confirmed experimentally both in vitro (using cancer cell cultures) and in vivo (using cancer models in mice). According to the obtained results, ssDNA significantly suppresses cancer development and tumor growth, allowing consideration of them as novel candidates for anti-cancer drugs.
Keyphrases
- circulating tumor
- papillary thyroid
- cell death
- cell free
- nucleic acid
- single molecule
- signaling pathway
- squamous cell
- high resolution
- binding protein
- genome wide
- type diabetes
- lymph node metastasis
- drinking water
- young adults
- squamous cell carcinoma
- skeletal muscle
- childhood cancer
- dna methylation
- bone marrow
- circulating tumor cells
- risk assessment
- mass spectrometry
- insulin resistance
- human milk
- human health
- preterm infants
- cell cycle arrest
- high fat diet induced