Insulin amyloid fibrils interact directly with the NLRP3, resulting in inflammasome activation and pyroptotic cell death.
Wakako MoriNaoe KanekoAyaka NakanishiTamotsu ZakoJunya MasumotoPublished in: International journal of immunopathology and pharmacology (2022)
Insulin ball formation and cytotoxicity may be associated with NLRP3 inflammasome activation followed by pyroptotic cell death.