Cerebrospinal Fluid Pterins, Pterin-Dependent Neurotransmitters, and Mortality in Pediatric Cerebral Malaria.

Matthew P RubachJackson P MukembaSalvatore M FlorenceBert K LopansriKeith HylandRyan A SimmonsCharles R LangelierSara NakielnyJoseph L DeRisiTsin W YeoNicholas M AnsteyJ Brice WeinbergEsther D MwaikamboDonald L Granger

Published in: The Journal of infectious diseases (2022)

Despite low systemic BH4, CSF BH4 was elevated and associated with increased odds of survival in CM. Coma in malaria is not explained by deficiency of BH4-dependent neurotransmitters. Elevated CSF neopterin was 100% sensitive for CM diagnosis and warrants further assessment of its clinical utility for ruling out CM in malaria-endemic areas.

Keyphrases

cerebrospinal fluid
plasmodium falciparum
subarachnoid hemorrhage
risk factors
type diabetes
coronary artery disease
replacement therapy
clinical evaluation