Effect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes: A Systematic Review and Meta-Analysis.

Qi ChenZi WangJingwei ZhouZhenjie ChenYan LiShichao LiHukang ZhaoSunil V BadveJicheng Lv

Published in: Clinical journal of the American Society of Nephrology : CJASN (2020)

Urate-lowering therapy did not produce benefits on the clinical outcomes, including major adverse cardiovascular events, all-cause mortality, and kidney failure. Thus, there is insufficient evidence to support urate lowering in patients to improve kidney and cardiovascular outcomes.

Keyphrases

cardiovascular events
end stage renal disease
coronary artery disease
ejection fraction
newly diagnosed
chronic kidney disease
cardiovascular disease
prognostic factors
peritoneal dialysis
emergency department
stem cells
metabolic syndrome
bone marrow
skeletal muscle
patient reported