Adequacy of cefepime concentrations in the early phase of critical illness: a case for precision pharmacotherapy.

(P < 0.001) predicted a lower %ƒT>8. Central nervous system infection source was protective [i.e., associated with a higher %ƒT>8; P = 0.008)] DISCUSSION: During early critical illness, cefepime concentrations were inadequate in a significant proportion of patients. Antimicrobial optimization is needed to improve the precision of pharmacotherapy in the critically ill.