Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn's Disease and Ulcerative Colitis.

Linmin HuSiqing WuYuelong ShuKai SuChunliang WangDanni WangQiangsheng HeXinyu ChenWenjing LiNingning MiPeng XieJinyu ZhaoShiyong ZhangJinqiu YuanJianbang XiangBin Xia

Published in: Journal of Crohn's & colitis (2023)

Our prospective cohort study provides evidence that MSDP increases the risk of CD in adult offspring, whereas no evidence supports their causal association. Additionally, smoking and genetic susceptibility had a numerically amplified effect with MSDP on CD and UC, but the interaction lacked statistical significance.

Keyphrases

smoking cessation
ulcerative colitis
high fat diet
genome wide
copy number
dna methylation
type diabetes
physical activity
adipose tissue
pregnant women
young adults