Black Americans with sickle cell disease (SCD) demonstrate accelerated epigenetic pace of aging compared to Black Americans without SCD.
Melanie E GarrettBrandon LeKyle J BourassaMichelle F DennisDaniel HatchQing YangPaula TanabeNirmish ShahFaith S LuysterCharity OyedejiJohn J StrouseHarvey J CohenNathan A KimbrelJean C BeckhamMitchell R KniselyMarilyn J TelenAllison E Ashley-Kochnull nullPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2024)
These data support our hypothesis that individuals with SCD experience accelerated biological aging as measured by global epigenetic variation. The assessment of epigenetic measures of biological aging may prove useful to identify which SCD patients would most benefit from clinical interventions to reduce mortality.