Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.
Goretti Durán PiñeiroRaquel CruzSantiago AguínFrancisco BarrosJosé María GiráldezBeatriz BernárdezIrene ZarraRafael López-LópezÁngel CarracedoMaría Jesús LamasPublished in: Cancer chemotherapy and pharmacology (2021)
Our findings highlight the potential usefulness of SNPs in different genes involved in drug metabolism and repair DNA to predict the response and survival to CRT. ABCC2 is a potential predictor of OS in patients with HNC.
Keyphrases
- locally advanced
- rectal cancer
- squamous cell carcinoma
- neoadjuvant chemotherapy
- radiation therapy
- phase ii study
- human health
- genome wide
- cell free
- dna repair
- heart failure
- single molecule
- emergency department
- gene expression
- dna methylation
- lymph node
- risk assessment
- adverse drug
- oxidative stress
- cardiac resynchronization therapy
- climate change
- nucleic acid
- cell migration