Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III).
Carla QueirósSílvia VinhasJéssica OliveiraAndreia LeiteAna M G SilvaMaria RangelPublished in: Molecules (Basel, Switzerland) (2022)
Functionalization of xanthene fluorophores with specific receptor units is an important topic of research aiming for the development of new analytical tools for biological sciences, clinical diagnosis, food and environmental monitoring. Herein, we report a new dihydrorosamine containing two active amino groups, which was functionalized with 3-benzyloxy-1-(3'-carboxypropyl)-2-methyl-4-pyridinone through an amide coupling strategy. Benzylated mono- and di-functionalized dihydrorosamine derivatives (H in position 9 of the xanthene) were obtained, but with modest reaction yields, requiring long and laborious purification procedures. Looking for a more efficient approach, rhodamine 110 was selected to react with the carboxypropyl pyridinone, enabling the isolation of the corresponding mono- and di-functionalized derivatives in amounts that depend on the excess of pyridinone added to the reaction. The structure of all compounds was established by 1 H and 13 C NMR, MS (ESI) and their absorption and emission properties were evaluated in dichloromethane. The fluorescence behavior of the debenzylated mono-rhodamine 110 derivative in the presence of Fe(III) was studied, making it an interesting fluorogenic dye for future optical sensing applications.
Keyphrases
- fluorescent probe
- quantum dots
- ms ms
- high resolution
- solid state
- single molecule
- molecularly imprinted
- energy transfer
- mass spectrometry
- biofilm formation
- human health
- magnetic resonance
- aqueous solution
- metal organic framework
- multiple sclerosis
- electron transfer
- current status
- liquid chromatography
- highly efficient
- risk assessment
- recombinant human
- water soluble