Diabetes has no additional impact on retinal ganglion cell loss in a mouse model of spontaneous glaucoma.
Silvia MaestroniArianna BelvedereIlaria ViganòCesare MeoniFederico Di MatteoDaniela GabelliniFrancesco Maria BandelloLuisa PierroGianpaolo ZerbiniPublished in: European journal of ophthalmology (2022)
In presence of glaucoma, diabetes is unable to induce further retinal ganglion cells loss. The hypothesis that the mechanism leading to retinal ganglion cells loss may be shared by the two diseases cannot be ruled out. Whether early diabetes-driven retinal neurodegeneration could be prevented by neuroprotective treatment proven to be effective in case of glaucoma, remains to be clarified.
Keyphrases
- type diabetes
- induced apoptosis
- cardiovascular disease
- optic nerve
- mouse model
- glycemic control
- cell cycle arrest
- optical coherence tomography
- cell death
- stem cells
- endoplasmic reticulum stress
- cell therapy
- signaling pathway
- diabetic retinopathy
- cataract surgery
- adipose tissue
- oxidative stress
- bone marrow
- insulin resistance
- blood brain barrier
- brain injury