Characterization of the interaction between platelet factor 4 and homogeneous synthetic low molecular weight heparins.

Thi-Huong NguyenYongmei XuSven BrandtMartin MandelkowRicarda RaschkeUlrike StrobelMihaela DelceaWen ZhouJian LiuAndreas Greinacher

Published in: Journal of thrombosis and haemostasis : JTH (2019)

We provide a template for characterizing interactions of newly developed heparin-based anticoagulant drugs with proteins, especially PF4 and the resulting potential antigenicity.

Keyphrases

venous thromboembolism
atrial fibrillation
growth factor
molecularly imprinted
human health
drug induced
high resolution
climate change
mass spectrometry
simultaneous determination