Distinct difference in tumor-infiltrating immune cells between Wilms' tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies.

Chisato YokotaJun NakataKoji TakanoHiroko NakajimaHiromu HayashibaraHikaru MinagawaYasuyoshi ChibaRyuichi HirayamaNoriyuki KijimaManabu KinoshitaYoshiko HashiiAkihiro TsuboiYoshihiro OkaYusuke OjiAtsushi KumanogohHaruo SugiyamaNaoki KagawaHaruhiko Kishima

Published in: Neuro-oncology advances (2021)

Our results clearly demonstrated that WT1 peptide vaccine and anti-PD-1 antibody therapies worked in the different steps of cancer-immunity cycle and that the combination of the two therapies could work synergistically against glioblastoma.

Keyphrases

papillary thyroid
copy number
gene expression
young adults
lymph node metastasis