GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload.

Jieyun YouXuan LiFangjie DaiJun LiuQi ZhangWei Guo

Published in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2023)

In conclusion, our results demonstrate that GSDMD serves as a key executioner of pyroptosis in cardiac remodeling induced by pressure overload. GSDMD-mediated pyroptosis activates JNK and p38 signaling pathways, and this may provide a new therapeutic target for cardiac remodeling induced by pressure overload.

Keyphrases

left ventricular
nlrp inflammasome
signaling pathway
cell death
heart failure
induced apoptosis
cell proliferation
pi k akt
atrial fibrillation