Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes.

Soyeon JangSoyoung JangSi-Yong KimJiwon KoEungyung KimJi Yeong ParkHyejin HyungJin Hong LeeSu-Geun LimSijun ParkJunkoo YiHeon-Jin LeeMyoung Ok KimHyun-Shik LeeZae Young Ryoo

Published in: Journal of inflammation research (2021)

Mechanistically, Lin28a exacerbated psoriasis-like inflammation through the activation of the extracellular-signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 signaling (STAT 3) by targeting proinflammatory cytokine interleukin-6 (IL-6).

Keyphrases

cell proliferation
transcription factor
signaling pathway
oxidative stress
pi k akt
atopic dermatitis
nuclear factor
protein kinase
immune response
wound healing