Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.

Katherine E OlsonLisa M Kosloski-BilekKristi M AndersonBreha J DiggsBarbara E ClarkJohn M GledhillScott J ShandlerR Lee MosleyHoward E Gendelman

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

Vasoactive intestinal peptide receptor 2 can elicit immune transformation in a model of Parkinson's disease (PD). Such immunomodulatory capabilities can lead to neuroprotection by attenuating microglial activation and by slowing degradation of neuronal cell bodies and termini in MPTP-intoxicated mice. The protective mechanism arises from altering a Th1/Th2 immune cytokine response into an anti-inflammatory and neuronal sparing profile. These results are directly applicable for the development of novel PD therapies.

Keyphrases

cerebral ischemia
anti inflammatory
high fat diet induced
brain injury
inflammatory response
single cell
subarachnoid hemorrhage
stem cells
lipopolysaccharide induced
type diabetes
metabolic syndrome
blood brain barrier
adipose tissue
mesenchymal stem cells
neuropathic pain
robot assisted