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Impact of Selective Immunosuppressive Therapy on Subsequent Immune-Related Adverse Events After Immune Checkpoint Inhibitor-Induced Colitis Treatment.

Antonio Pizuorno MachadoMalek ShatilaIsabella C Glitza OlivaMehmet AltanBilal SiddiquiYan ZhouKrishnavathana VaratharajaluHao Chi ZhangAnusha ThomasYinghong Wang
Published in: American journal of clinical oncology (2023)
New irAEs usually occur more than 6 months after SIT completion for initial colitis event. Severe diarrhea grade and higher number of SIT infusions appeared to have protective effect to lower the occurrence of new irAEs. Otherwise, the type of SIT or individual dosage of infliximab did not affect the occurrence of subsequent irAEs.
Keyphrases
  • risk assessment
  • ulcerative colitis
  • stem cells
  • combination therapy
  • mesenchymal stem cells