Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth.

Published in: Pain and therapy (2020)

Gabapentinoids remain a vital tool in the pain physician's multimodal armamentarium, but these drugs may not be effective in every clinical situation. Individuals with central sensitization and pain associated with slow-wave sleep deficits and potentially persons with comorbid addictions may benefit the most. The gabapentinoids appear to possess no addictive potential on their own, based on laboratory and clinical data, but they may be abused by persons with opioid use disorders; consequently, cautious risk stratification must take place.

Keyphrases

pain management
chronic pain
neuropathic pain
traumatic brain injury
emergency department
primary care
physical activity
electronic health record
machine learning
sleep quality
climate change
deep learning