VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Anne-Maj SamuelssonTheda Ulrike Patricia BartolomaeusHarithaa AnandakumarIrene ThowsenElham NikpeyJianhua HanLajos MarkoKenneth FinneOlav TenstadJohannes EcksteinNikolaus BerndtTitus KuehneSarah KedzioraIbrahim SultanTrude SkogstrandTine V KarlsenHarri NurmiSofia Kirke ForslundEntela BollanoKari AlitaloDominik N MullerHelge WiigPublished in: Cardiovascular research (2023)
This study shows that the VEGF-B TG accelerates metabolic maladaptation which precedes structural cardiomyopathy in experimental hypertension and ultimately leads to systolic HF.