Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer's disease: A genetic and proteomic multi-cohort study.

Cynthia PicardAlexandre PoirierStéphanie BélangerAnne Labonté Daniel AuldJudes Poiriernull null

Published in: PloS one (2019)

PCSK9 levels differ between control and AD brains and its protein levels correlate with those of other lipoproteins and AD biomarkers even before the onset of the disease. PCSK9 regulation seems to be under tight genetic control in females only, with specific variants that could predispose to increased AD risk.

Keyphrases

low density lipoprotein
copy number
genome wide
blood brain barrier
cognitive decline
dna methylation
small molecule
gene expression
protein protein
mild cognitive impairment