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Separating the Good from the Bad: Tumor-Infiltrating Tregs Have Increased Fucosylation.

Stephanie L SilveriaMichel DuPage
Published in: Cancer immunology research (2023)
Regulatory T cells (Treg) can suppress antitumor immune responses, and their presence in tumors is associated with worse prognoses in most cancers. Strategies to neutralize Treg-mediated suppression in tumors without immune-related adverse events, however, are challenging due to the essential role of Tregs in maintaining immune homeostasis. In this issue, Pinioti and colleagues identify fucosylation as a critical regulator of Treg function in tumors that can be targeted therapeutically without impacting immune homeostasis. See related article by Pinioti et al., p. 1611 (3) .
Keyphrases
  • regulatory t cells
  • immune response
  • dendritic cells
  • transcription factor
  • childhood cancer