Genetic anticipation of breast cancer among BRCA1/BRCA2 mutation carriers: A retrospective study.

Aviya KedmiLuna KadouriIftach SagyTamar HamburgerGabriel LevinNoa Zimhony-NissimTamar Peretz

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2022)

Breast cancer appeared to be diagnosed at an earlier age in successive generations among BRCA mutation carriers and non-carriers. The fact that we also observed a downshift at age of diagnosis in non-carrier pairs emphasizes that other factors (environmental, lifestyle, or social) may influence the age at diagnosis.

Keyphrases

breast cancer risk
healthcare
metabolic syndrome
cardiovascular disease
mental health
physical activity
type diabetes
gene expression
dna methylation
risk assessment
climate change
human health
copy number